# Combined STRING + Enrichr Enrichment Report

Generated: 2026-05-20T10:28:23

## Overview

This report summarizes functional enrichment results from:
- **STRING** (network-aware enrichment)
- **Enrichr** (gene set–based enrichment)

Results are reported across multiple clustering resolutions (k values).
No single k is assumed to be optimal; trends and consistency are emphasized.

## STRING enrichment summary

### k = 5

- Clusters: 5
- Median cluster size: 1e+01 genes
- Clusters enriched: 5 (1 fraction)
- Total enriched terms: 13
- Median best FDR: 0.0025

### k = 7

- Clusters: 7
- Median cluster size: 6 genes
- Clusters enriched: 4 (0.57 fraction)
- Total enriched terms: 11
- Median best FDR: 0.00415

### k = 15

- Clusters: 11
- Median cluster size: 4 genes
- Clusters enriched: 6 (0.55 fraction)
- Total enriched terms: 8
- Median best FDR: 0.017

### STRING enrichment sources

**k = 5**

- HPO: 5 terms (best FDR 4.61e-08)
- NetworkNeighborAL: 2 terms (best FDR 0.0381)
- PMID: 2 terms (best FDR 0.0075)
- SMART domains: 2 terms (best FDR 0.01)
- TISSUES: 2 terms (best FDR 0.0272)

**k = 7**

- HPO: 4 terms (best FDR 4.61e-08)
- PMID: 2 terms (best FDR 0.0075)
- SMART domains: 2 terms (best FDR 0.01)
- TISSUES: 2 terms (best FDR 0.0272)
- NetworkNeighborAL: 1 terms (best FDR 0.0064)

**k = 15**

- HPO: 5 terms (best FDR 0.0023)
- GO Biological Process: 1 terms (best FDR 0.0277)
- NetworkNeighborAL: 1 terms (best FDR 0.0064)
- TISSUES: 1 terms (best FDR 0.0449)

## Enrichr enrichment summary

### k = 5

- Clusters: 5
- Median cluster size: 1e+01 genes
- Clusters enriched: 5 (1 fraction)
- Total enriched terms: 249
- Median best FDR: 0.00935

### k = 7

- Clusters: 7
- Median cluster size: 6 genes
- Clusters enriched: 7 (1 fraction)
- Total enriched terms: 339
- Median best FDR: 0.00761

### k = 15

- Clusters: 11
- Median cluster size: 4 genes
- Clusters enriched: 11 (1 fraction)
- Total enriched terms: 644
- Median best FDR: 0.00499

### Enrichr enrichment sources

**k = 5**

- GO_Biological_Process_2025: 140 terms
- Reactome_2022: 35 terms
- Human_Phenotype_Ontology: 30 terms
- GO_Molecular_Function_2025: 29 terms
- GO_Cellular_Component_2025: 7 terms
- OMIM_Disease: 5 terms
- MSigDB_Hallmark_2020: 3 terms

**k = 7**

- GO_Biological_Process_2025: 204 terms
- Reactome_2022: 42 terms
- GO_Molecular_Function_2025: 40 terms
- Human_Phenotype_Ontology: 31 terms
- GO_Cellular_Component_2025: 11 terms
- MSigDB_Hallmark_2020: 6 terms
- OMIM_Disease: 5 terms

**k = 15**

- GO_Biological_Process_2025: 379 terms
- Human_Phenotype_Ontology: 92 terms
- Reactome_2022: 71 terms
- GO_Cellular_Component_2025: 44 terms
- GO_Molecular_Function_2025: 41 terms
- MSigDB_Hallmark_2020: 11 terms
- OMIM_Disease: 6 terms

## Interpretation guidance

- Lower k values tend to show broader, more generic enrichment.
- Intermediate k values often reveal pathway-level or tissue-specific biology.
- Higher k values produce more specific but sparser enrichment signals.

Concordance between STRING and Enrichr strengthens biological confidence.
Divergence may reflect literature bias, domain-level signal, or annotation gaps.

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End of report.