# Combined STRING + Enrichr Enrichment Report

Generated: 2026-05-20T11:25:29

## Overview

This report summarizes functional enrichment results from:
- **STRING** (network-aware enrichment)
- **Enrichr** (gene set–based enrichment)

Results are reported across multiple clustering resolutions (k values).
No single k is assumed to be optimal; trends and consistency are emphasized.

## STRING enrichment summary

### k = 3

- Clusters: 3
- Median cluster size: 2e+01 genes
- Clusters enriched: 1 (0.33 fraction)
- Total enriched terms: 13
- Median best FDR: 1.86e-07

### k = 8

- Clusters: 8
- Median cluster size: 6 genes
- Clusters enriched: 4 (0.5 fraction)
- Total enriched terms: 4
- Median best FDR: 0.00176

### k = 11

- Clusters: 10
- Median cluster size: 4 genes
- Clusters enriched: 4 (0.4 fraction)
- Total enriched terms: 5
- Median best FDR: 0.0069

### STRING enrichment sources

**k = 3**

- HPO: 10 terms (best FDR 1.86e-07)
- PMID: 3 terms (best FDR 1.93e-05)

**k = 8**

- HPO: 2 terms (best FDR 1.54e-05)
- NetworkNeighborAL: 1 terms (best FDR 0.0064)
- PMID: 1 terms (best FDR 4.05e-06)

**k = 11**

- HPO: 3 terms (best FDR 1.54e-05)
- NetworkNeighborAL: 1 terms (best FDR 0.0064)
- TISSUES: 1 terms (best FDR 0.0449)

## Enrichr enrichment summary

### k = 3

- Clusters: 3
- Median cluster size: 2e+01 genes
- Clusters enriched: 3 (1 fraction)
- Total enriched terms: 90
- Median best FDR: 0.0134

### k = 8

- Clusters: 8
- Median cluster size: 6 genes
- Clusters enriched: 8 (1 fraction)
- Total enriched terms: 400
- Median best FDR: 0.00787

### k = 11

- Clusters: 10
- Median cluster size: 4 genes
- Clusters enriched: 10 (1 fraction)
- Total enriched terms: 441
- Median best FDR: 0.00727

### Enrichr enrichment sources

**k = 3**

- GO_Biological_Process_2025: 38 terms
- GO_Molecular_Function_2025: 24 terms
- Human_Phenotype_Ontology: 16 terms
- GO_Cellular_Component_2025: 8 terms
- OMIM_Disease: 2 terms
- MSigDB_Hallmark_2020: 1 terms
- Reactome_2022: 1 terms

**k = 8**

- GO_Biological_Process_2025: 245 terms
- Human_Phenotype_Ontology: 64 terms
- GO_Molecular_Function_2025: 44 terms
- Reactome_2022: 28 terms
- GO_Cellular_Component_2025: 10 terms
- OMIM_Disease: 6 terms
- MSigDB_Hallmark_2020: 3 terms

**k = 11**

- GO_Biological_Process_2025: 249 terms
- Human_Phenotype_Ontology: 68 terms
- GO_Molecular_Function_2025: 46 terms
- Reactome_2022: 41 terms
- GO_Cellular_Component_2025: 25 terms
- MSigDB_Hallmark_2020: 8 terms
- OMIM_Disease: 4 terms

## Interpretation guidance

- Lower k values tend to show broader, more generic enrichment.
- Intermediate k values often reveal pathway-level or tissue-specific biology.
- Higher k values produce more specific but sparser enrichment signals.

Concordance between STRING and Enrichr strengthens biological confidence.
Divergence may reflect literature bias, domain-level signal, or annotation gaps.

---

End of report.