# Combined STRING + Enrichr Enrichment Report

Generated: 2026-06-08T15:57:04

## Overview

This report summarizes functional enrichment results from:
- **STRING** (network-aware enrichment)
- **Enrichr** (gene set–based enrichment)

Results are reported across multiple clustering resolutions (k values).
No single k is assumed to be optimal; trends and consistency are emphasized.

## STRING enrichment summary

### k = 3

- Clusters: 3
- Median cluster size: 2e+01 genes
- Clusters enriched: 2 (0.67 fraction)
- Total enriched terms: 25
- Median best FDR: 0.000136

### k = 11

- Clusters: 9
- Median cluster size: 4 genes
- Clusters enriched: 2 (0.22 fraction)
- Total enriched terms: 8
- Median best FDR: 0.00275

### k = 15

- Clusters: 7
- Median cluster size: 4 genes
- Clusters enriched: 1 (0.14 fraction)
- Total enriched terms: 4
- Median best FDR: 0.0023

### STRING enrichment sources

**k = 3**

- HPO: 21 terms (best FDR 1.14e-06)
- PMID: 2 terms (best FDR 0.0043)
- SMART domains: 2 terms (best FDR 0.0067)

**k = 11**

- HPO: 4 terms (best FDR 0.0023)
- SMART domains: 2 terms (best FDR 0.0168)
- NetworkNeighborAL: 1 terms (best FDR 0.0047)
- RCTM: 1 terms (best FDR 0.0032)

**k = 15**

- HPO: 4 terms (best FDR 0.0023)

## Enrichr enrichment summary

### k = 3

- Clusters: 3
- Median cluster size: 2e+01 genes
- Clusters enriched: 3 (1 fraction)
- Total enriched terms: 117
- Median best FDR: 0.0127

### k = 11

- Clusters: 9
- Median cluster size: 4 genes
- Clusters enriched: 9 (1 fraction)
- Total enriched terms: 387
- Median best FDR: 0.00906

### k = 15

- Clusters: 7
- Median cluster size: 4 genes
- Clusters enriched: 7 (1 fraction)
- Total enriched terms: 192
- Median best FDR: 0.00906

### Enrichr enrichment sources

**k = 3**

- GO_Biological_Process_2025: 80 terms
- Human_Phenotype_Ontology: 11 terms
- GO_Molecular_Function_2025: 10 terms
- GO_Cellular_Component_2025: 9 terms
- OMIM_Disease: 4 terms
- MSigDB_Hallmark_2020: 2 terms
- Reactome_2022: 1 terms

**k = 11**

- GO_Biological_Process_2025: 205 terms
- Human_Phenotype_Ontology: 67 terms
- Reactome_2022: 41 terms
- GO_Cellular_Component_2025: 35 terms
- GO_Molecular_Function_2025: 27 terms
- MSigDB_Hallmark_2020: 6 terms
- OMIM_Disease: 6 terms

**k = 15**

- GO_Biological_Process_2025: 70 terms
- Human_Phenotype_Ontology: 40 terms
- Reactome_2022: 26 terms
- GO_Cellular_Component_2025: 24 terms
- GO_Molecular_Function_2025: 21 terms
- MSigDB_Hallmark_2020: 8 terms
- OMIM_Disease: 3 terms

## Interpretation guidance

- Lower k values tend to show broader, more generic enrichment.
- Intermediate k values often reveal pathway-level or tissue-specific biology.
- Higher k values produce more specific but sparser enrichment signals.

Concordance between STRING and Enrichr strengthens biological confidence.
Divergence may reflect literature bias, domain-level signal, or annotation gaps.

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End of report.